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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK1
All Species:
19.09
Human Site:
S624
Identified Species:
35
UniProt:
Q9P0L2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P0L2
NP_061120.3
795
89003
S624
E
Q
L
R
E
R
R
S
V
A
Y
N
G
P
P
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
S625
E
Q
L
R
E
R
R
S
A
A
Y
N
G
P
P
Rhesus Macaque
Macaca mulatta
XP_001115611
778
86745
N609
R
Q
V
R
D
Q
Q
N
L
P
Y
G
V
T
P
Dog
Lupus familis
XP_536123
782
87409
S611
E
Q
L
R
E
R
R
S
A
A
Y
N
G
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHJ5
795
88528
S624
E
Q
L
R
E
R
R
S
A
A
Y
N
G
R
P
Rat
Rattus norvegicus
O08678
793
88216
S624
E
Q
L
R
E
R
R
S
A
A
Y
S
G
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
N622
E
Q
L
R
E
R
R
N
A
T
Y
N
G
P
P
Chicken
Gallus gallus
Q9IA88
798
88848
G598
R
K
N
A
R
A
K
G
F
L
G
L
N
K
I
Frog
Xenopus laevis
NP_001085126
792
88624
Y624
R
D
R
R
T
A
T
Y
N
G
P
P
A
S
P
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
S752
S
A
L
Y
Q
S
P
S
D
S
P
P
P
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
E1021
G
P
S
A
N
N
A
E
A
T
I
W
S
K
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
D352
S
E
F
Q
E
T
T
D
S
G
S
N
P
M
R
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
S473
T
V
S
I
L
P
T
S
L
P
Q
I
H
R
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
68.9
95.9
N.A.
94.9
94.3
N.A.
92.8
30.4
88.6
27.8
N.A.
N.A.
N.A.
40.7
N.A.
Protein Similarity:
100
99.3
80.2
96.8
N.A.
97.3
96.9
N.A.
95.9
51.3
94.2
44
N.A.
N.A.
N.A.
51
N.A.
P-Site Identity:
100
93.3
26.6
93.3
N.A.
86.6
86.6
N.A.
80
0
13.3
13.3
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
93.3
66.6
93.3
N.A.
86.6
93.3
N.A.
86.6
13.3
13.3
26.6
N.A.
N.A.
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.9
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.4
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
16
0
16
8
0
47
39
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
8
0
0
8
8
0
0
0
0
0
0
% D
% Glu:
47
8
0
0
54
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
8
0
16
8
8
47
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
8
8
0
0
8
% I
% Lys:
0
8
0
0
0
0
8
0
0
0
0
0
0
16
0
% K
% Leu:
0
0
54
0
8
0
0
0
16
8
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
8
0
8
8
0
16
8
0
0
47
8
0
0
% N
% Pro:
0
8
0
0
0
8
8
0
0
16
16
16
16
39
62
% P
% Gln:
0
54
0
8
8
8
8
0
0
0
8
0
0
0
0
% Q
% Arg:
24
0
8
62
8
47
47
0
0
0
0
0
0
16
8
% R
% Ser:
16
0
16
0
0
8
0
54
8
8
8
8
8
8
8
% S
% Thr:
8
0
0
0
8
8
24
0
0
16
0
0
0
16
0
% T
% Val:
0
8
8
0
0
0
0
0
8
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
8
0
0
54
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _